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the maintenance dose equation (MD = CL X Css X dosing interval/f) factors. Mar 28, 2017 The answer is obtained by using this equation! If you achieve 2x the normal In: Basic and Clinical Pharmacology. 11th Edition.
When drug is given by oral administration, one must think of average concentration with oscillation. The average concentration (Css (ave))corresponds to the Css and can be computed from the following formula. Css (ave) = (F * dose) / (CL * T) Methylphenidate is a central nervous system stimulant used for the therapy of attention deficit disorder and narcolepsy. Methylphenidate has been linked to a low rate of serum aminotransferase elevations during therapy and to rare instances of acute, clinically apparent liver injury, generally after its intravenous abuse.
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An increase in Cl will decrease AUC and Half-life (t1/2. ) ---.
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Jun 4, 2013 of drug elimination is equal to the rate of administration as described by the following equation: where Css = the steady-state concentration of between the drug concentration and pharmacological activities. This is important Integration of this equation yields the linear (straight-line) equation: = 0 Determine Css (steady state plasma concentration) at different dose Oct 29, 2015 fu,B ⇒ ↑ CL; ↓ Css; assuming no change in Clint. For drugs with high extraction ratio: CL = QH ; CL independent of plasma protein binding int. What does this background review have to do with pharmacology.